Evaluation of estrogen and G protein-coupled estrogen receptor 1 (GPER) levels in drug-naïve patients with attention deficit hyperactivity disorder (ADHD).
Identifieur interne : 000981 ( Main/Exploration ); précédent : 000980; suivant : 000982Evaluation of estrogen and G protein-coupled estrogen receptor 1 (GPER) levels in drug-naïve patients with attention deficit hyperactivity disorder (ADHD).
Auteurs : Nilfer Sahin [Turquie] ; Hatice Altun ; Ergül Belge Kuruta ; Ebru F Nd KlSource :
- Bosnian journal of basic medical sciences [ 1840-4812 ] ; 2018.
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Abstract
Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs). G protein-coupled estrogen receptor 1 (GPER) is a member of mERs, and despite limited research on the levels of GPER in patients with psychiatric diseases, a role of GPER in such conditions has been suggested. Here we evaluated serum estrogen and GPER levels in children with attention deficit hyperactivity disorder (ADHD) in relation to their age- and gender-matched healthy controls. A total of 82 children were included in the study, 47 drug- naïve patients with ADHD (age: 6-12 years; male/female: 34/13) and 35 healthy controls (age: 6-12 years; male/female: 19/16). The subgroups according to ADHD types were inattentive, hyperactive/impulsive, and combined. Serum estrogen was measured using an immunoassay system, while serum GPER was determined using a commercial sandwich enzyme-linked immunosorbent assay kit. Estrogen levels in children with ADHD were similar as in control group, while GPER levels were significantly lower in ADHD group compared to controls (p < 0.05). Logistic regression analysis showed a significant association between GPER levels and ADHD (p < 0.05), and no association between estrogen levels and ADHD (p > 0.05). No significant differences were found in GPER and estrogen levels between ADHD subgroups (p > 0.05). To the best of our knowledge, this study is the first to investigate estrogen and GPER levels in ADHD. Our preliminary findings suggest a relationship between serum GPER levels and ADHD, and this should be further investigated.
DOI: 10.17305/bjbms.2018.2942
PubMed: 29659348
Affiliations:
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Mugla</wicri:regionArea><wicri:noRegion>Mugla</wicri:noRegion></affiliation></author><author><name sortKey="Altun, Hatice" sort="Altun, Hatice" uniqKey="Altun H" first="Hatice" last="Altun">Hatice Altun</name></author><author><name sortKey="Kuruta, Ergul Belge" sort="Kuruta, Ergul Belge" uniqKey="Kuruta E" first="Ergül Belge" last="Kuruta">Ergül Belge Kuruta</name></author><author><name sortKey="F Nd Kl, Ebru" sort="F Nd Kl, Ebru" uniqKey="F Nd Kl E" first="Ebru" last="F Nd Kl">Ebru F Nd Kl</name></author></analytic><series><title level="j">Bosnian journal of basic medical sciences</title><idno type="eISSN">1840-4812</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity (blood)</term><term>Case-Control Studies</term><term>Child</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Estradiol (blood)</term><term>Estrogens (blood)</term><term>Female</term><term>Humans</term><term>Male</term><term>Receptors, Estrogen (blood)</term><term>Receptors, G-Protein-Coupled (blood)</term><term>Regression Analysis</term><term>Sex Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de régression</term><term>Enfant</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Oestradiol (sang)</term><term>Oestrogènes (sang)</term><term>Récepteurs couplés aux protéines G (sang)</term><term>Récepteurs des oestrogènes (sang)</term><term>Test ELISA</term><term>Trouble déficitaire de l'attention avec hyperactivité (sang)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Estradiol</term><term>Estrogens</term><term>Receptors, Estrogen</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Oestradiol</term><term>Oestrogènes</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs des oestrogènes</term><term>Trouble déficitaire de l'attention avec hyperactivité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Child</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Regression Analysis</term><term>Sex Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de régression</term><term>Enfant</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Test ELISA</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs). G protein-coupled estrogen receptor 1 (GPER) is a member of mERs, and despite limited research on the levels of GPER in patients with psychiatric diseases, a role of GPER in such conditions has been suggested. Here we evaluated serum estrogen and GPER levels in children with attention deficit hyperactivity disorder (ADHD) in relation to their age- and gender-matched healthy controls. A total of 82 children were included in the study, 47 drug- naïve patients with ADHD (age: 6-12 years; male/female: 34/13) and 35 healthy controls (age: 6-12 years; male/female: 19/16). The subgroups according to ADHD types were inattentive, hyperactive/impulsive, and combined. Serum estrogen was measured using an immunoassay system, while serum GPER was determined using a commercial sandwich enzyme-linked immunosorbent assay kit. Estrogen levels in children with ADHD were similar as in control group, while GPER levels were significantly lower in ADHD group compared to controls (p < 0.05). Logistic regression analysis showed a significant association between GPER levels and ADHD (p < 0.05), and no association between estrogen levels and ADHD (p > 0.05). No significant differences were found in GPER and estrogen levels between ADHD subgroups (p > 0.05). To the best of our knowledge, this study is the first to investigate estrogen and GPER levels in ADHD. Our preliminary findings suggest a relationship between serum GPER levels and ADHD, and this should be further investigated.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Altun, Hatice" sort="Altun, Hatice" uniqKey="Altun H" first="Hatice" last="Altun">Hatice Altun</name><name sortKey="F Nd Kl, Ebru" sort="F Nd Kl, Ebru" uniqKey="F Nd Kl E" first="Ebru" last="F Nd Kl">Ebru F Nd Kl</name><name sortKey="Kuruta, Ergul Belge" sort="Kuruta, Ergul Belge" uniqKey="Kuruta E" first="Ergül Belge" last="Kuruta">Ergül Belge Kuruta</name></noCountry><country name="Turquie"><noRegion><name sortKey="Sahin, Nilfer" sort="Sahin, Nilfer" uniqKey="Sahin N" first="Nilfer" last="Sahin">Nilfer Sahin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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